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CTCAE 4.03 - June 14, 2010 : Renal and urinary disorders 151Renal and urinary disorders Grade Adverse Event 1 2 3 4 5Urinary tract obstruction Asymptomatic; clinical ordiagnostic observations only Symptomatic but nohydronephrosis, sepsis orrenal dysfunction; urethraldilation, urinary or suprapubiccatheter indicated Symptomatic and alteredorgan function (e.g.,hydronephrosis, or renaldysfunction); electiveradiologic, endoscopic oroperative interventionindicated Life-threateningconsequences; urgentintervention indicated Death Definition: A disorder characterized by blockage of the normal flow of contents of the urinary tract.

Urinary tract pain Mild pain Moderate pain; limitinginstrumental ADLSevere pain; limiting self care ADL - -Definition: A disorder characterized by a sensation of marked discomfort in the urinary tract.

Urinary urgency Present Limiting instrumental ADL;medical managementindicated - - -Definition: A disorder characterized by a sudden compelling urge to urinate.

Urine discoloration Present - - - -Definition: A disorder characterized by a change in the color of the urine.

This kind of eruption has also been well described with EGFR inhibitors, and is more or less confined to the seborrheic areas (areas rich in sebaceous glands): the face (especially the nose, the cheeks, the forehead and the chin), the scalp, the neck and retroauricular area, the shoulders and the upper trunk (typically V-shaped reflecting the density of the sebaceous glands in that skin area).

Sometimes the lower parts of the back, the abdomen, the buttocks and even the arms and legs can be involved as well, whereas the palms of hands and soles of feet (containing no hair follicles) are spared.

Papulopustular rash is not reported with the other multikinase inhibitors discussed on this website.