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Urine discoloration Present - - - -Definition: A disorder characterized by a change in the color of the urine.

This kind of eruption has also been well described with EGFR inhibitors, and is more or less confined to the seborrheic areas (areas rich in sebaceous glands): the face (especially the nose, the cheeks, the forehead and the chin), the scalp, the neck and retroauricular area, the shoulders and the upper trunk (typically V-shaped reflecting the density of the sebaceous glands in that skin area).

Sometimes the lower parts of the back, the abdomen, the buttocks and even the arms and legs can be involved as well, whereas the palms of hands and soles of feet (containing no hair follicles) are spared.

Papulopustular rash is not reported with the other multikinase inhibitors discussed on this website.

Papulopustular skin lesions have an early infiltration with T-lymphocytes, followed by a hyperkeratotic, Ectatic appearance of the Follicular infundibula and a florid, neutrophilic suppurative infiltrate.